Here's a quick fix for the Windows 10 KB45516384 sound issue

Microsoft has released a support doc describing a “compatibility change” which compromises sound quality in certain games in Windows 10 version 1903 after users installed update KB4515384.

After customer feedback led Microsoft to disable query support and multi-channel audio features in certain games, devices with the September 2019 cumulative update may experience missing channels and questionable game audio.

Windowslatest outlined a couple of ways which you can solve the audio problems, which don’t involve uninstalling KB4515384:

• In Games, open settings and disable multi-channel audio

Alternatively, you can do this from the control panel:

• In the control panel, look for 3rd party audio device control panels and disable Multi-Channel audio or Virtual Surround Sound.

Official bug fixes are expected to be included in the upcoming cumulative update for Windows 10 later this month.